EFFECTS OF CO-ADMINISTRATION OF PROMETHAZINE AND ARTEMETHER-LUMEFANTRINE IN PLASMODIUM berghei berghei INFECTED MICE
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 5000
ABSTRACT
Malaria is the 2nd leading cause of death from infectious diseases in Africa, after HIV/AIDS. It is a major public health problem in Nigeria where it accounts for most cases of hospital visits and deaths than any other country in the world. This study evaluated the effects of coadministration of promethazine and Artemether-Lumenfantrine in mice infected with Plasmodium berghei berghei. The mice were grouped into six groups of 6 mice each. Group 2 – 6 were inoculated with Plasmodium berghei berghei groups. Drug administration was carried out orally and for 5 days, 72 hours after parasite inoculation and parasitaemia seen. The mice were sacrificed on the 8th day. Blood samples were collected and organs harvested for haematological and histopathological evaluations. Parameters evaluated include average parasitaemia inhibition, haematological indices, organ-body weight ratio and liver transaminases. The liver, kidney and heart were subjected to histological evaluation. The result showed that promethazine alone had no significant parasitaemia inhibition but the coadministration of promethazine (both 25 mg/kg and 50 mg/kg) and artemether-lumenfantrine gave a marginal reduction but not a significant one compared to Artemether-lumenfantrine alone. Promethazine showed a significant reduction in Haemoglobin, Pack cell volume, RBC, and increase in neutrophils compared to Artemether-Lumenfantrine alone, but no effects compared to the infected control. Its co-administration of promethazine (25 mg/kg) with Artemether-Lumenfantrine gave a marginal reduction, but not a significant difference in Hb, PCV and RBC. The 50mg/kg dose of promethazine co-administered with artemetherlumenfantrine gave lower values of PVC, Hb, RBC than the 25mg/kg promethazine dose plus artemether-lumenfantrine. The liver transaminases were significantly (p≤0.05) increased for Promethazine co-administered with artemether-lumenfantrine compared to Artemtherlumenfantrine alone, although the values of AST, ALT and ALP were still mostly within the normal ranges ( AST-20-298U/l, ALT-17-80U/l, ALP-30-110U/l). Histology sections of the liver showed slight increase in hepatic congestion and lymphocyte hyperplasia, renal sections showed no significant changes while the heart sections showed slight lymphocyte hyperplasia. The study showed that co-administration of Promethazine and Artemether-lumenfantrine possesses no advantage over Artemether-Lumenfantrine alone and it has tendencies of toxicity with continuous use.
Related Project Materials
THE ROLE OF MASS MEDIA IN SOCIALIZING CHILDREN (A CASE STUDY OF EDO STATE)
ABSTRACT
Journalists willing to advocate for children and young people face the challenge of counterbalancing negative i...
LEADERSHIP STYLE AND ITS IMPACT ON ORGANIZATIONAL PERFORMANCE
Abstract
This project is designed to investigate leadership styles and its impact on organizational per...
The Role of Financial Forecasting in the Management of Public Universities in Osun State
Background of the Study
Financial forecasting is a key element in the management of public univer...
STATISTICAL STUDY OF REPORTED CRIME CASES IN NIGERIA
ABSTRACT
Crime is a public wrong. It is an act strongly disapproved by society. Crime includes...
THE INFLUENCE OF BUDGETING SOFTWARE ON FINANCIAL PLANNING
THE INFLUENCE OF BUDGETING SOFTWARE ON FINANCIAL PLANNING
The objectives of this research are to: (1) analyze the impact of budgeting sof...
The Impact of Event Marketing on Women Entrepreneurs in Lokoja Local Government Area, Kogi State
Chapter One: Introduction
1.1 Background of the Study
Event marketing has become an essential tool for promoting businesses, fo...
Assessment of Managerial Accounting Practices in NGO Financial Efficiency in Baruten LGA
Background of the Study
Non-governmental organizations (NGOs) play a crucial role in d...
HOME ENVIRONMENT AND ITS EFFECT ON ACADEMIC PERFORMANCE AMONG SECONDARY SCHOOL STUDENTS
ABSTRACT
The home influences the students at the most possible time of his life at a time when his mind...
DESIGN AND IMPLEMENTATION OF A FIXED ASSET MANAGEMENT INFORMATION SYSTEM (A CASE STUDY OF UNITED AFRICAN COMPANY OF NIGERIA (UACN) DEVELOPMENT COMPANY PLC LAGOS)
ABSTRACT
With the rapid development in Computer Technology, most organization have embraced the use of computer resource...
IMPACT OF PUBLIC WORK NIGERIA LIMITED QUARRY ACTIVITIES ON PHYSICAL ENVIRONMENT OF VWANG DISTRICT, JOS SOUTH LOCAL GOVERNMENT AREA OF PLATEAU STATE, NIGERIA
ABSTRACT
Construction activities at all levels depend to a large extent on quarry stone aggregate for structural and none structural-deve...
